Prof. Dr. Ulrich Schatzschneider
Associate Professor of Bioinorganic Chemistry
Institut für Anorganische Chemie
Julius-Maximilians-Universität Würzburg Am Hubland
The main focus of work in the Schatzschneider group in the field of bioorganometallic and medicinal inorganic chemistry is to utilize the inherent properties of transition metal compounds, like redox activity, light absorption and emission, as well as ligand exchange reactions to develop novel diagnostic and therapeutic agents with potential applications in human medicine.
In our major project, novel transition-metal carbonyl complexes are prepared and evaluated for their applications as CO-releasing molecules (CORMs), in particular those which can be induced by external stimuli like enzymatic reactions (ET-CORMs) and photoactivation (PhotoCORMs).
Significant work is also devoted to the attachment of such CORMs to biological carrier systems like cell-penetrating peptides (CPPs) and nanoparticles for selective enrichment in cells and tissues.
Selected Recent Publications
- G. Dördelmann, H. Pfeiffer, A. Birkner, U. Schatzschneider, "Silicium dioxide nanoparticles as carriers for photoactivatable CO releasing molecules (PhotoCORMs)", Inorg. Chem. 2011, 50, 4362-4367.
- S. Romanski, B. Kraus, U. Schatzschneider, J.-M. Neudörfl, S.
Amslinger, H.-G. Schmalz, "Acyloxy-butadiene-Fe(CO)3 Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs)", Angew. Chem. Int.
Ed. 2011, 50, 2392-2396.
- H. Pfeiffer, A. Rojas, J. Niesel, U. Schatzschneider, "Sonogashira and "Click" reactions in the N-terminal and side chain functionalization of peptides with [Mn(CO)3(tpm)]+-based CO releasing molecules (tpm = tris(pyrazolyl)methane)", Dalton Trans. 2009, 4292-4298.