Martin Feelisch, Ph.D.
Professor of Experimental Medicine & Integrative Biology
University of Southampton
Faculty of Medicine
Clinical and Experimental Sciences
Southampton General Hospital
SAB, Level F, MP 810
Tremona Road, Southampton, SO16 6YD
+44 (0)23 8079 6891 Phone
+44 (0)23 8051 1761 Fax
Martin has a long-standing interest in analytical chemistry, cardiovascular pharmacology, drug metabolism, disease mechanisms, and the chemical biology of nitric oxide (NO), and has received numerous awards/honors in recognition of his research achievements in these areas. His more recent interests focus on the physiological significance of nitros(yl)ation reactions and the role of NO storage forms in blood and tissues; biomarkers of cardiovascular disease and adaptation to hypoxia; hypoxic signalling and altitude physiology; regulation of mitochondrial function and redox signalling; and systems-based approaches to assess the role of nitrite, nitrate and other NO-related products in vivo. Work in his laboratory is both hypothesis- and curiosity-driven and includes basic as well as translational research projects in all of the above areas.
Selected Recent Publications
- Levett DZ, Fernandez BO, Riley HL, Martin DS, Mitchell K, Leckstrom CA, Ince C, Whipp BJ, Mythen MG, Montgomery HE, Grocott MP, Feelisch M; for the Caudwell Extreme Everest Research Group. The role of nitrogen oxides in human adaptation to hypoxia. Sci Rep. 2011;1:109
- Fago A, Jensen FB, Tota B, Feelisch M, Olson KR, Helbo S, Lefevre S, Mancardi D, Palumbo A, Sandvik GK, Skovgaard N. Integrating nitric oxide, nitrite
and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach. Comp Biochem Physiol A Mol Integr Physiol. 2012 May;162(1):1-6
- Milsom AB, Fernandez BO, Garcia-Saura MF, Rodriguez J, Feelisch M. Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products. Antioxid Redox Signal. 2012 Aug 1;17(3):422-32