Ulf Simonsen, MD, PhD
Professor of Pharmacology
Department of Biomedicine
Wilhelm Meyers Allé 4
8000 Aarhus C
T: +4587167685 or +4560202613
The research group aims to develop novel pharmacological approaches to improve endothelial function in cardiovascular disease. Endothelial cell function and signal transduction is investigated under normal and pathophysiological conditions both in collaboration with basic science as well as clinical departments. Endothelial dysfunction is also linking cardiovascular disease to erectile dysfunction, and plays an important role in the development of pulmonary hypertension. Heading a research group in pulmonary and cardiovascular pharmacology with assistant prof. Elise Røge Hedegaard (10 people, 4 PhD students, 2 medical students, 4 science students, 2 technicians). Author or co-author on > 130 peer reviewed papers in international journals and several book chapters. Co-inventor of amine-transport inhibitor for treatment of erectile dysfunction. H-index 25.
Selected Recent Publications
- Dalsgaard T, Kroigaard C, Misfeldt M, Bek T, Simonsen U. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. Br. J. Pharmacol. 2010 Jul;160(6):1496-508.
- Boedtkjer E, Praetorius J, Matchkov VV, Stankevicius E, Mogensen S, Füchtbauer A, Simonsen U, Füchtbauer EM, Aalkjaer C. Disruption of Na+,HCO3 --cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca2+-sensitivity and hypertension development in mice. Circulation 2011;124:1819-29.
- Stankevičius E, Dalsgaard T, Kroigaard C, Beck L, Boedtkjer E, Misfeldt MW, Nielsen G, Schjorring O, Hughes A, Simonsen U. Opening of small and intermediate calcium-activated potassium channels induce relaxation mainly mediated by NO release in large arteries and EDHF in small arteries from rat. J Pharmacol. Exp. Ther. 2011;339:842-50.
- Simonsen, U., Wadsworth, R.M., Buus, N.H., Mulvany, M.J. In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery. J. Physiol. 1999; 516.1:271-282.
Hernanz R, Alonso MJ, Zibrandtsen H., Salaices M., Simonsen U. Simultaneous measurements of nitric oxide concentration and hyporeactivity in rat superior mesenteric artery exposed to endotoxin. Cardiovascular Research 2004; 62, 202-211.