Home The Action Management Committee Santiago Lamas (ES)

Tue,21Oct2014

Prof. Santiago Lamas

Research Professor
Deparment of Cell Biology and Immunology
Centro de Biología Molecular “Severo Ochoa”( CBMSO)
Consejo Superior de Investigaciones Cientificas  (CSIC).
Nicolás Cabrera, 1.
28049 Madrid, Spain This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Research Interests
Our  group investigates  the  molecular, biochemical, and cellular mechanisms that underlie the pathophysiology of the vascular wall.  We  have  a fundamental interest in the endothelial response to oxidative and nitrosative stress through specific posttranslational modifications such as S-glutathionylation, S-nitrosylation and tyrosine nitration as well as redox signaling in endothelial cells. We are also interested in the role of the TGF-endothelin-1 axis in fibrosis  as this is a pathology  inherently  related  to endothelial dysfunction.  Finally, another aim of our group is to find  new antiangiogenic  strategies in order to halt tumor growth.

Selected Recent Publications

  • Nitric oxide signaling: classical, less classical, and nonclassical mechanisms. Martínez-Ruiz A, Cadenas S, Lamas S. Free Radic Biol Med 51:17-29, 2011.
  • Cyclosporine A-Induced nitration of tyrosine 34  MnSOD in endothelial cells: role of mitochondrial superoxide. Redondo-Horcajo M, Romero N, Martínez-Acedo P, Martínez-Ruiz A, Quijano C, Lourenço CF, Movilla N, Enríquez JA, Rodríguez-Pascual F, Rial E, Radi R, Vázquez J, Lamas S.  Cardiovasc Res 87:356-65, 2010.
  • Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability. Rodríguez-Pascual F, Redondo-Horcajo M, Magán-Marchal N, Lagares D, Martínez-Ruiz A, Kleinert H, Lamas S. Mol Cell Biol 28:7139-55, 2008.

ESF

COST

POLICY STATEMENT: Biomedicine and Molecular Biosciences Action BM1005 is funded by COST, through its implementing agent the European Science Foundation.