Bernhard Mayer

Full Professor
Karl-Franzens University Graz
Tel.: +43-316-380-5567
Fax: +43-316-380-9890
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Research interests

• role of lipid metabolism in endothelial function
• nitric oxide/cGMP signaling in the cardiovascular system
• biological chemistry of nitric oxide
• vascular bioactivation of organic nitrates

Selected Recent Publications

• Wölkart G, Beretta M, Wenzl MV, Stessel H, Schmidt K, Maeda N, Mayer B, Schrammel A. Tolerance to Nitroglycerin Through Proteasomal Downregulation of Aldehyde Dehydrogenase-2 in a Genetic Mouse Model of Ascorbate Deficiency. Br J Pharmacol. 2012 Nov 30. doi: 10.1111/bph.12081. [Epub ahead of print]
• Lang BS, Gorren AC, Oberdorfer G, Wenzl MV, Furdui CM, Poole LB, Mayer B, Gruber K. Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. J Biol Chem. 2012 Nov 2;287(45):38124-34. doi: 10.1074/jbc.M112.371716. Epub 2012 Sep 17.
• Beretta M, Wölkart G, Schernthaner M, Griesberger M, Neubauer R, Schmidt K, Sacherer M, Heinzel FR, Kohlwein SD, Mayer B. Vascular bioactivation of nitroglycerin is catalyzed by cytosolic aldehyde dehydrogenase-2. Circ Res. 2012 Feb 3;110(3):385-93. doi: 10.1161/CIRCRESAHA.111.245837. Epub 2011 Dec 29.
• Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med. 2011 Aug 21;17(9):1076-85. doi: 10.1038/nm.2439.
• Wölkart G, Schrammel A, Dörffel K, Haemmerle G, Zechner R, Mayer B. Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist. Br J Pharmacol. 2012 Jan;165(2):380-9. doi: 10.1111/j.1476-5381.2011.01490.x.